Human ENPP-2 / Autotaxin Protein

• Catalog Number: orb640153
• Category: Proteins
• Description: Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.
• Reactivity: Human
• Tag: N-6×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 94.5 kDa
• Target: ENPP-2
• Protein Sequence: NP_001035181
• Source: Human ENPP-2, His Tag (orb640153) is expressed from human 293 cells (HEK293). It contains AA Asp 49 - Ile 863 (Accession # NP_001035181).
• Expression System: HEK293
• Expression Region: Asp 49 - Ile 863
• Endotoxins: 1.0 EU per μg
• NCBI: NP_001035181
• Storage: -20℃
• Buffer/Preservatives: 50 mM Tris, 150 mM NaCl, pH 7.5
• Alternative names: ENPP-2,E-NPP 2,Autotaxin,LysoPLD,ATX,PDNP2,ATX-X,N
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 94.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.