Human E-Cadherin / Cadherin-1 (155-709) Protein, Fc Tag (MALS verified)

• Catalog Number: orb1733280
• Category: Proteins
• Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 87.0 kDa
• Target: E-Cadherin
• Source: Human E-Cadherin (155-709) Protein, Fc Tag (orb1733280) is expressed from human 293 cells (HEK293). It contains AA Asp 155 - Ala 709 (Accession # P12830-1).
• Expression System: HEK293
• Expression Region: Asp 155 - Ala 709
• Endotoxins: 1.0 EU per μg
• Storage: -20℃
• Buffer/Preservatives: 20 mM Tris, 150 mM NaCl, pH8.0
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 87.0 kDa . The protein migrates as 50 kDa and 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.