Human DR6 / TNFRSF21 Protein

• Catalog Number: orb257879
• Category: Proteins
• Description: Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) is also known as death receptor 6 (DR6), which is a member of the TNF-receptor superfamily. TNFRSF21 contains one death domain and four TNFR-Cys repeats. TNFRSF21 / DR6 has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 60.2 kDa
• Target: DR6
• Protein Sequence: AAH17730
• Source: Human DR6, Fc Tag (orb257879) is expressed from human 293 cells (HEK293). It contains AA Gln 42 - Leu 350 (Accession # AAH17730).
• Expression System: HEK293
• Expression Region: Gln 42 - Leu 350
• Endotoxins: 1.0 EU per μg
• NCBI: AAH17730
• Storage: -20℃
• Buffer/Preservatives: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
• Alternative names: TNFRSF21,DR6,CD358,BM-018
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.2 kDa. The protein migrates as 80-95kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human DR6 protein