Human CYR61 protein

• Catalog Number: orb107703
• Category: Proteins
• Description: Cysteine-rich angiogenic inducer 61 (Cyr61) encoded by the Cyr61 gene is a dynamically expressed, multifunctionalmatricellular protein and it is also a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family. Cyr61plays essential roles in cardiovascular development during embryogenesis and regulates inflammation, wound healing andfibrogenesis in the adult. Aberrant CCN1 expression is associated with myriad pathologies, including various cancers anddiseases associated with chronic inflammation. Mature human Cyr61 shares 93 % amino acid sequence identity with mouse andrat Cyr61. Cyr61 consists of four domains. There are an IGFBP domain, a VWF type C domain, a TSP type I domain, and acysteine knot domain.
• Tested applications: HPLC, SDS-PAGE
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Conjugation: Unconjugated
• MW: 39.4 kDa
• Target: CYR61
• Protein Sequence: TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTKGLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLCPQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTRNNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTNDNPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYCGSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANEAAFPFYRLFN DIHKFRD
• Biological Origin: E.coli
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in citrate buffer solution, 300 mM NaCl, pH3.0.
• Alternative names: Human Cysteine-rich Angiogenic protein
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human CYR61 protein