You have no items in your shopping cart.
Cart summary
Item 1 of 1
| Catalog Number | orb257974 |
|---|---|
| Category | Proteins |
| Description | CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis. |
| Reactivity | Human |
| Tag | C-10×His |
| Form/Appearance | Powder |
| Purity | 95% |
| Conjugation | Unconjugated |
| MW | 15.4 kDa |
| Target | CTLA-4 |
| Protein Sequence | NP_005205.2 |
| Source | Human CTLA-4, His Tag (orb257974) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # P16410-1). |
| Expression System | HEK293 |
| Expression Region | Ala 37 - Phe 162 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_005205.2 |
| Storage | -20℃ |
| Buffer/Preservatives | PBS, pH7.4 |
| Alternative names | CTLA4,CD152 Read more... |
| Note | For research use only |
| Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.4 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to different extent glycosylation. |
| Expiration Date | 6 months from date of receipt. |
Ross, Elle et al. Therapeutic monoclonal antibodies in human breast milk: a case study Melanoma Res, 24, 177-180 (2014)
SDS-PAGE analysis of Human CTLA-4 protein
- Item 1 of 1
Human CTLA-4 / CD152 Protein [orb257378]
Unconjugated
98%
39.9 kDa
Human CTLA-4, Fc Tag (orb257378) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Ser 160 (Accession # P16410-1).
1 mg, 200 μg - Item 1 of 1
Human CTLA-4 / CD152 Protein [orb383500]
Unconjugated
95%
40.6 kDa
Human CTLA-4, mouse IgG2a Fc tag, low endotoxin (orb383500) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # P16410-1).
100 μg, 1 mg 
Recombinant Human CTLA-4/CD152 Protein, His Tag [orb1552604]
≥90% as determined by SDS-PAGE
This protein contains the human CTLA4(Lys36-Asp161) was fused with the C-terminal His Tag and expressed in Mammalian cells.
100 μg, 50 μgRecombinant Human CTLA-4/CD152 Protein, Flag Tag [orb1552606]
≥90% as determined by SDS-PAGE
This protein contains the human CTLA4(Lys36-Asp161) was fused with the C-terminus Flag Tag and expressed in Mammalian cells.
100 μg, 50 μgRecombinant Human CTLA-4/CD152 Protein, Fc Tag [orb1552608]
≥90% as determined by SDS-PAGE
This protein contains the human CTLA4(Lys36-Asp161) was fused with the C-terminus Fc Tag and expressed in Mammalian cells.
100 μg, 50 μg
Submit a review
Filter by Rating
- 5 stars
- 4 stars
- 3 stars
- 2 stars
- 1 stars