Human Complement Factor D / CFD Protein

• Catalog Number: orb612152
• Category: Proteins
• Description: Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 26.3 kDa
• Target: Complement Factor D
• Source: Human Complement Factor D, His Tag (orb612152) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Ala 253 (Accession # P00746-1).
• Expression System: HEK293
• Expression Region: Ile 26 - Ala 253
• Endotoxins: 1.0 EU per μg
• NCBI: NP_001919.2
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: 50 mM Tris, 150 mM NaCl, pH8.0
• Alternative names: CFD,Adipsin,PFD,DF,Complement factor D
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 28 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.