Human CD5 Protein

• Catalog Number: orb257280
• Category: Proteins
• Description: T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 40.5 kDa
• Target: CD5
• Protein Sequence: NP_055022
• Source: Human CD5, His Tag (orb257280) is expressed from human 293 cells (HEK293). It contains AA Arg 25 - Pro 372 (Accession # NP_055022).
• Expression System: HEK293
• Expression Region: Arg 25 - Pro 372
• Endotoxins: 1.0 EU per μg
• NCBI: NP_055022
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: CD5,LEU1
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40.5 kDa. The protein migrates as 45-53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human CD5 protein