Human CD209 / DC-SIGN Protein

• Catalog Number: orb624211
• Category: Proteins
• Description: CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
• Reactivity: Human
• Tag: N-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 41.3 kDa
• Target: CD209
• Protein Sequence: NP_066978.1
• Source: Human CD209, His Tag (orb624211) is expressed from human 293 cells (HEK293). It contains AA Gln 59 - Ala 404 (Accession # Q9NNX6-1).
• Expression System: HEK293
• Expression Region: Gln 59 - Ala 404
• Endotoxins: 1.0 EU per μg
• NCBI: NP_066978.1
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: DC-SIGN,CD209,DC-SIGN1,CLEC4L
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 41.3 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.