Human CCL3 / MIP-1 alpha Protein

• Catalog Number: orb1496155
• Category: Proteins
• Description: CCL3, also know as MIP-1-alpha, is monokine with inflammatory and chemokinetic properties. CCL3 is an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
• Reactivity: Human
• Tag: N-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 9.7 kDa
• Target: CCL3
• Source: Human CCL3, His Tag (orb1496155) is expressed from E. coli cells. It contains AA Ser 24 - Ala 92 (Accession # P10147-1).
• Expression System: E. coli
• Expression Region: Ser 24 - Ala 92
• Endotoxins: 0.1 EU per μg
• NCBI: NP_002974.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: 20 mM Tris,150 mM NaCl,0.2 M Arginine,1 mM EDTA,pH8.0
• Alternative names: C-C motif chemokine 3,MIP1-(a),AI323804,CCL3,chemo
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 9.7 kDa. The protein migrates as 12-13 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.