Human Cadherin-6 / KCAD / CDH6 Protein

• Catalog Number: orb257240
• Category: Proteins
• Description: Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 85%
• Conjugation: Unconjugated
• MW: 67.2 kDa & 63.4 kDa
• Target: Cadherin-6
• Protein Sequence: AAH00019
• Source: Human Cadherin-6, His Tag (orb257240) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Ala 615 (Accession # AAH00019).
• Expression System: HEK293
• Expression Region: Thr 19 - Ala 615
• Endotoxins: 1.0 EU per μg
• NCBI: AAH00019
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: CDH6,CAD6,KCAD,K-cadherin,Cadherin-6
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The Human Cadherin-6 will be further processed into mature form (Ser 54-Ala 615). The protein has a calculated MW of 67.2 kDa (pro-form) and 63.4 kDa (mature-form). The protein migrates as 86-96 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Cadherin-6 protein