Human B7-H6 / NCR3LG1 Protein

• Catalog Number: orb545764
• Category: Proteins
• Description: The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 28.6 kDa
• Target: B7-H6
• Protein Sequence: NP 001189368.1
• Source: Human B7-H6 Protein, His Tag (orb545764) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Ser 262 (Accession # Q68D85-1).
• Expression System: HEK293
• Expression Region: Asp 25 - Ser 262
• Endotoxins: 1.0 EU per μg
• NCBI: 001189368.1
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: B7-H6,NCR3LG1,B7 Homolog 6
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.6 kDa. The protein migrates as 38-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.