Human B7-H2 / ICOSLG Protein

• Catalog Number: orb257206
• Category: Proteins
• Description: ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
• Reactivity: Human
• Tag: C-8×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 27.8 kDa
• Target: B7-H2
• Protein Sequence: NP_056074
• Source: Human B7-H2, His Tag (orb257206) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Ser 258 (Accession # NP_056074).
• Expression System: HEK293
• Expression Region: Asp 19 - Ser 258
• Endotoxins: 1.0 EU per μg
• NCBI: NP_056074
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,I
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.8 kDa. The protein migrates as 45-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human B7-H2 protein