Human ADAM8 / CD156a Protein

• Catalog Number: orb257173
• Category: Proteins
• Description: Disintegrin and metalloproteinase domain-containing protein 8 is also known as ADAM8, Cell surface antigen MS2 and CD antigen CD156a, which belongs to the ADAM (a disintegrin and metalloprotease domain) family. ADAM family play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. ADAM8 / CD156a contains 1 disintegrin domain, 1 EGF-like domain and 1 peptidase M12B domain. ADAM8 / MS2 / CD156a is expressed on neutrophils and monocytes. ADAM8 / MS2 possible involvement in extravasation of leukocytes.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 53.8 kDa
• Target: ADAM8
• Protein Sequence: AAI15405.1
• Source: Human ADAM8, His Tag (orb257173) is expressed from human 293 cells (HEK293). It contains AA Ile 17 - Pro 497 (Accession # AAI15405.1).
• Expression System: HEK293
• Expression Region: Ile 17 - Pro 497
• Endotoxins: 1.0 EU per μg
• NCBI: AAI15405.1
• Storage: -20℃
• Buffer/Preservatives: 50 mM Tris, 150 mM NaCl, pH7.5
• Alternative names: ADAM8,MS2,CD156a
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 53.8 kDa. Two main fragments bands are visible with apparent MW of 57-65 kDa and 35-40 kDa respectively in reduced SDS-PAGE as a result of its being prone to proteolytic cleavage.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human ADAM8 protein