Human Activin RIIA / ACVR2A Protein

• Catalog Number: orb1101193
• Category: Proteins
• Description: Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.
• Reactivity: Human
• Tag: N-Fc
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 39.9 kDa
• Target: Activin RIIA
• Source: Human ACVR2A, Fc Tag (orb1101193) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 135 (Accession # P27037-1).
• Expression System: HEK293
• Biological Activity: Immobilized Human Activin A, premium grade at 5 μg/mL (100 μL/well) can bind Human ACVR2A, Fc Tag with a linear range of 0.4-25 ng/mL (QC tested).
• Expression Region: Ala 20 - Pro 135
• Endotoxins: 1.0 EU per μg
• NCBI: NP_001607.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Alternative names: Activin receptor type IIA,ACTRIIA
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 39.9 kDa. The protein migrates as 50-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Immobilized Human Activin A, premium grade (Cat. No. orb16656) at 5 μg/mL (100 μL/well) can bind Human ACVR2A, Fc Tag (Cat. No. orb1101193) with a linear range of 0.4-25 ng/mL (QC tested).