Human Activin RIB / ACVR1B Protein

• Catalog Number: orb624206
• Category: Proteins
• Description: Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 13.3 kDa
• Target: Activin RIB
• Protein Sequence: AAH00254
• Source: Human Activin RIB, His Tag (orb624206) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Glu 126 (Accession # P36896-1).
• Expression System: HEK293
• Expression Region: Ser 24 - Glu 126
• Endotoxins: 1.0 EU per μg
• NCBI: AAH00254
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.3 kDa. The protein migrates as 16-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.