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HPV16 E2 Antibody
Catalog Number: orb2637325
| Catalog Number | orb2637325 |
|---|---|
| Category | Antibodies |
| Description | The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | TVG 261 |
| Tested applications | WB |
| Reactivity | Virus |
| Isotype | Mouse IgG1, kappa |
| Immunogen | Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2 |
| Antibody Type | Primary Antibody |
| Dilution range | Western blot: 1-2ug/ml |
| Purity | Protein A/G affinity |
| Conjugation | Unconjugated |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Hazard Information | This HPV16 E2 antibody is available for research use only. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Buffer/Preservatives | 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide |
| Note | For research use only |
| Application notes | Optimal dilution of the HPV16 E2 antibody should be determined by the researcher. |
| Expiration Date | 12 months from date of receipt. |
SDS-PAGE analysis of purified, BSA-free HPV16 E2 antibody (TVG 261) as confirmation of integrity and purity.
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