HO-PEG16-OH

SKU: orb1307413

Description

HO-PEG16-OH is a polyethylene glycol (PEG) spacer commonly utilized as a linker in constructing PROTAC molecules. Its hydrophilic and flexible chain aids in improving solubility and bioavailability, which is critical for both in vitro biochemical assays and in vivo pharmacological studies of targeted protein degradation.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6812-36-8
• MW: 722.86
• Purity: 97.87% (May vary between batches)
• Formula: C₃₂H₆₆O₁₇
• SMILES: OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs consist of two distinct ligands linked by a connector: one ligand targets an E3 ubiquitin ligase, while the other targets a specific protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PROTACLinker, PROTAC Linker, PROTAC Linkers, PEGs, HOPEG16OH, HO-PEG-16-OH, HO-PEG16-OH, HO PEG16 OH, inhibit, Inhibitor

Compound Identifiers

PubChem CID

81262