HLA DP/DQ/DR mAb (IVA12), InVivoPure

• Catalog Number: orb2568764
• Category: Antibodies
• Description: The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.
• Target: HLA DP/DQ/DR
• Clonality: Monoclonal
• Species/Host: Mouse
• Isotype: IgG1 k
• Conjugation: Unconjugated
• Reactivity: Human
• Form/Appearance: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
• Concentration: ≥ 0.5 mg/ mL
• Buffer/Preservatives: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
• Purity: ≥ 90 % (CGE, reducing conditions) Endotoxin level ≤ 2 EU/mg
• Immunogen: Animals were immunized with the Priess human B cell line
• Tested applications: FC, WB
• Antibody Type: Primary Antibody
• Clone Number: IVA12
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: anti-panHLA-II, anti-panHLA II, Anti-HLA-DP/DQ/DR
• Note: For research use only
• Expiration Date: 12 months from date of receipt.