Halcinonide

SKU: orb1310930

Description

Halcinonide is a potent synthetic corticosteroid used as an anti-inflammatory agent in topical formulations. It is applied in dermatological research to study glucocorticoid receptor signaling and its effects on skin inflammation in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3093-35-4
• MW: 454.96
• Purity: 99.94% (May vary between batches)
• Formula: C₂₄H₃₂ClFO₅
• SMILES: CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CCl
• Target: Glucocorticoid Receptor,Smo
• Solubility: DMSO:45 mg/mL (98.91 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:4 mg/mL (8.79 mM)

Bioactivity

• In Vivo:
  Halcinonide interacts with hormone receptors in the cytoplasm, eliciting anti-inflammatory effects. It is employed in the treatment of certain skin disorders.
• In Vitro:
  After administering 0.1% Halcinonide cream for three days, the total number of peritoneal white blood cells in rats decreased from 270 million to 120.73 million. The same dosage of the drug, when applied to the surface of injured rat cecum for 3 and 7 days, significantly reduced the average adhesion scores, with the adhesion rates in the experimental and control groups being 43.3% and 100%, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Halciderm, Halcimat, Halcinonida, Halcinonide, Glucocorticoid Receptor, GlucocorticoidReceptor, Inhibitor, inhibit, SQ 18566, SQ18566, SQ-18566, Smoothened, Smo

Compound Identifiers

PubChem CID

443943