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Catalog Number | orb1996097 |
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Category | Antibodies |
Description | GSTP1 Recombinant Antibody [SAIC-22D-22] |
Species/Host | Rabbit |
Clonality | Recombinant |
Tested applications | ELISA, FC, IF, IHC, SBR, WB |
Tag | Q15109 |
Immunogen | Human RAGE protein. |
Conjugation | Unconjugated |
Alternative names | advanced glycosylation end product-specific recept Read more... |
Note | For research use only |
Application notes | Dilution Info: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. |
Expiration Date | 12 months from date of receipt. |
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