GSK3395879

• Catalog Number: orb1910843
• Category: Small Molecules
• Description: GSK3395879 (GSK-3395879) is a novel potent, selective, orally bioavailable antagonist of TRPV4 with IC50 of 1 nM (hTRPV4); exhibits little or no activity against a broad panel of TRP channels (IC50 > 10µM for TRPA1, TRPV1, TRPM2, TRPM4, TRPM8, TRPC3, TRPC4, TRPC5, TRPC6); demonstrates the ability to inhibit TRPV4-mediated pulmonary edema in an in vivo rat model.
• CAS Number: [2215852-91-6]
• MW: 485.408817529678
• SMILES: S(C1C=CC(C(F)(F)F)=CC=1C#N)(N1C[C@@H]([C@](CO)(C1)O)OC1C=CC(C#N)=C(C=1)F)(=O)=O
• Formula: C₂₀H₁₅F₄N₃O₅S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.