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GSK J1

SKU: orb1222724

Description

GSKJ1 is a selective and potent histone demethylase inhibitor (GSK-J1) that has significant activity (IC50 60 nM for human JmjD3) in vitro and in cells using an ester derivative (GSK-J4: 1 μM 100 μM for human JmjD3) and thus can be used as control for target effects in vitro, and as ester derivative (GSK-J5) in cells. Recent data has shown that GSK-J1 also shows some activity (IC50 950 nM for Jarid1b, IC50 1.76 uM for Jarid1c) against H3K4me3/2/1 demethylases.

Images & Validation

Key Properties

CAS Number1373422-53-7
MW389.45
Purity>98% (HPLC)
FormulaC22H23N5O2
SMILESOC(=O)CCNC1=CC(=NC(=N1)C1=CC=CC=N1)N1CCC2=C(CC1)C=CC=C2
TargetJMJD3 (KDM6B)|UTX (KDM6A)
SolubilityDMSO : ≥ 33 mg/mL; 84.73 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSKJ1 | GSKJ 1 | GSKJ-1

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GSK J1 (orb1222724)

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200 mg
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5 mg
$ 80.00
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100 mg
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