Granzyme B GZMB Monoclonal Antibody

• Catalog Number: orb547267
• Category: Antibodies
• Description: Granzyme B GZMB Monoclonal Antibody
• Species/Host: Rabbit
• Clonality: Monoclonal
• Clone Number: AAHC-7
• Tested applications: ICC, IF, IHC, IP
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: A synthesized peptide derived from human Granzyme B This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
• Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Dilution range: IHC 1:50-1:200ICC/IF 1:50-1:200IP 1:50
• Form/Appearance: Liquid
• Conjugation: Unconjugated
• UniProt ID: P10144
• Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

IHC analysis of GZMB using anti-GZMB antibody on paraffin-embedded human T cell lymphoma.GZMB was detected in paraffin-embedded section.