GPCR Antibody

SKU: orb3169680

Description

Anti-GPR44/PTGDR2/CD294 Antibody is a humanized monoclonal antibody expressed in CHO cells targeting the GPCR GPR44 (CRTH2/PTGDR2). Featuring a huIgG1 heavy chain and a hukappa light chain, it binds specifically to the extracellular domain of GPR44, blocking the binding of its ligand PGD2. This antagonism inhibits PGD2-induced Gi protein-coupled signaling, restoring intracellular cAMP levels and reducing calcium mobilization, thereby inhibiting the chemotaxis and activation of Th2 cells, eosinophils, and basophils.

Key Properties

• Antibody Type: Inhibitor Antibody
• Clonality: Monoclonal
• Target: GPCR
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GPCR