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Goat anti Human Factor XII
Catalog Number: orb21989
| Catalog Number | orb21989 |
|---|---|
| Category | Antibodies |
| Description | Goat polyclonal antibody to Factor XII. |
| Species/Host | Goat |
| Clonality | Polyclonal |
| Antibody Type | Primary Antibody |
| Form/Appearance | Delipidated, heat inactivated, lyophilized, stable whole serum. No preservative added. Total protein concentration in the antiserum is about 50 mg/ml, the IgG concentration about 10 mg/ml. No foreign proteins added. |
| Conjugation | Unconjugated |
| Hazard Information | This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Biorbyt accepts no liability for any inaccuracies or omissions in this information. |
| UniProt ID | P00748 |
| Source | Factor XII (Hageman factor) is a single chain glycoprotein (MW 80,000). It is a serine protease zymogen. FXII is converted to an active enzyme by damage to vascular endothelium. In vitro activation is caused by glass or kaolin. Surface binding promotes activation by kallikrein. FXIIa activates prekallikrein and FXI. Kallikrein activates more FXII. Fragments of FXIIa activate FVII to FVIIa, and plasminogen to plasmin. The complement system is also activated by FXIIa. A link between fibrin clot and the subendothelium is formed by FXIIa crosslinking with fibrin, alpha-2 plasmin inhibitor, fibronectin and Van Willebrand factor. Purified plasma FXII is used as immunogen. Freund’s complete adjuvant is used in the first step of the immunization procedure. |
| RRID | AB_10748848 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Buffer/Preservatives | Delipidated, heat inactivated, lyophilized, stable whole serum. No preservative added. Total protein concentration in the antiserum is about 50 mg/ml, the IgG concentration about 10 mg/ml. No foreign proteins added. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
