GNE-140 racemic

• Catalog Number: orb1089835
• Category: Small Molecules
• Description: GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance.
• CAS Number: [1809794-70-4]
• MW: 499.0447
• SMILES: ClC1=C([H])C([H])=C([H])C([H])=C1SC1C(N([H])C(C2=C([H])SC([H])=C2[H])(C2C([H])=C([H])C(=C([H])C=2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C=1O[H])=O
• Formula: C₂₅H₂₃CLN₂O₃S₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.