GGTase-I protein

• Catalog Number: orb533491
• Category: Proteins
• Description: GGTase-I (Geranylgeranyltransferase-I) catalyzes the transfer of the farnesyl and geranylgeranyl groups from farnesyl and geranylgeranyl-diphosphate to proteins containing a C-terminal CaaX motif, where 'C' is a conserved cysteine that is the site of farnesyl modification, 'a' is usually an aliphatic amino acid, and 'X' is leucine or phenylalanine. Farnesyltransferase (FT) and GGTase-I are closely related, sharing a common α subunit and 30% identity in their β subunits.
• Clonality: Recombinant
• Form/Appearance: liquid (Supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM TECP and 5 µM ZnCl 2)
• Purity: > 90% (SDS-PAGE)
• MW: Theoretical MW: α: 44 kDa, β: 38 kDa
• Source: E. coli
• Storage: store at -80 °C
• Note: For research use only
• Application notes: Activity: 1 pmol of GGTase-I will transfer 5 pmol of Farnesyl to RhoA in 15 min at 37°C.
• Expiration Date: 6 months from date of receipt.