Furosemide

SKU: orb3029217

Description

Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54-31-9
• MW: 330.744
• Purity: 99.89% (May vary between batches)
• Formula: C₁₂H₁₁ClN₂O₅S
• SMILES: NS(=O)(=O)C1=CC(C(O)=O)=C(NCC2=CC=CO2)C=C1Cl
• Target: GABA Receptor,Na-K-Cl cotransporter
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.05 mM);DMSO:33.1 mg/mL (100.08 mM)

Bioactivity

• In Vitro:
  Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF. Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells. Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model. Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-Aminobutyric acid Receptor, liver scarring, kidney disease, inhibit, NaKCl cotransporter, Na-K-Cl cotransporter, NaKClcotransporter, NKCC, Inhibitor, hypertension, heart failure, Lasix, Furosemid, Furosemide, Furanthril, GABA Receptor, GABAReceptor, Gamma-aminobutyric acid Receptor, edema

Quick Database Links

Gene Symbol

GABA Receptor,Na-K-Cl cotransporter