Furosemide

SKU: orb3029217

Description

Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54-31-9
• MW: 330.744
• Purity: 99.89%
• Formula: C₁₂H₁₁ClN₂O₅S
• SMILES: NS(=O)(=O)C1=CC(C(O)=O)=C(NCC2=CC=CO2)C=C1Cl
• Target: GABA Receptor,Na-K-Cl cotransporter
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.05 mM);DMSO:33.1 mg/mL (100.08 mM)

Bioactivity

• In Vitro:
  Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF. Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells. Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model. Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-Aminobutyric acid Receptor, liver scarring, kidney disease, inhibit, NaKCl cotransporter, Na-K-Cl cotransporter, NaKClcotransporter, NKCC, Inhibitor, hypertension, heart failure, Lasix, Furosemid, Furosemide, Furanthril, GABA Receptor, GABAReceptor, Gamma-aminobutyric acid Receptor, edema

Quick Database Links

Gene Symbol

GABA Receptor,Na-K-Cl cotransporter