Fumagilin-105

SKU: orb2646123

Description

Fumagilin-105 is an AUTOTAC molecule that induces self-oligomerization of p62, leading to targeted autophagic degradation. It demonstrates potent activity with a DC50 of 0.7 µM against MetAP2 in HEK293 cells, making it a valuable tool for studying autophagy and targeted protein degradation in cellular models.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2410081-58-0
• MW: 784.98
• Formula: C₄₆H₆₀N₂O₉
• SMILES: C[C@@]1([C@@]2([C@@]3(CO3)CC[C@@H](OC(/C=C/C=C/C=C/C=C/C(NCCOCCOCCNCC4=CC(OCC5=CC=CC=C5)=CC=C4)=O)=O)[C@H]2OC)[H])[C@@H](CC=C(C)C)O1
• Target: Autophagy,AUTACs,p62,Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

153397128