FOXP1 Recombinant Antibody [RAB-S37]

• Catalog Number: orb1996223
• Category: Antibodies
• Description: FOXP1 Recombinant Antibody [RAB-S37]
• Species/Host: Rabbit
• Clonality: Recombinant
• Tested applications: ChIP, ELISA, FC, IF, IP
• Tag: Q9Y468
• Immunogen: This antibody was obtained by recombinant antibody (rAb) phage display recognizing L3MBTL1 protein under non-denaturing conditions.
• Conjugation: Unconjugated
• Alternative names: dJ138B7.3;H-L(3)MBT;l(3)mbt protein homolog;l(3)mb
• Note: For research use only
• Application notes: Dilution Info: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
• Expiration Date: 12 months from date of receipt.