Fmoc-Aeg(N3)-OH

• Catalog Number: orb2663715
• Category: Small Molecules
• Description: Fmoc-Aeg(N3)-OH is a click chemistry reagent characterized by its azide group that participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. This building block, which also reacts in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN group-containing molecules, facilitates the alteration of cytotoxicity through the creation of peptidomimetics such as Cilengitide, Piscidin 1, and MC3, MC4, MC5 receptor agonists. Its incorporation in molecules can lead to conformational restraint in peptidic structures due to amidic nitrogen alkylation, which results in structures such as N-methylated peptides, allows backbone derivatization, and enables the design of macrocycles through intramolecular cross-linking or stabilization of the main chain by intramolecular cyclization. Fmoc-Aeg(N3)-OH is a potential cornerstone for the construction of custom peptide nucleic acids (PNAs) and peptide synthesis.
• CAS Number: 1935981-35-3
• Purity: 98.00%
• MW: 366.37
• SMILES: [N-]=[N+]=NCCN(C(=O)OCC1C=2C=CC=CC2C=3C=CC=CC31)CC(=O)O
• Formula: C₁₉H₁₈N₄O₄
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.