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FKBP25/FKBP3 Protein, Human, Recombinant (His)
Catalog Number: orb1961254
| Catalog Number | orb1961254 |
|---|---|
| Category | Proteins |
| Description | FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. |
| Tag | N-6xHis |
| Purity | 98.00% |
| MW | 30 KDa (reducing condition) |
| UniProt ID | Q00688 |
| Protein Sequence | Met1-Asp224 |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. |
| Expression Region | Met1-Asp224 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | 0 |
| Expiration Date | 6 months from date of receipt. |
