FKBP14 Protein, Human, Recombinant (His)

• Catalog Number: orb1956319
• Category: Small Molecules
• Description: FKBP14 Protein, Human, Recombinant (His)
• Purity: 98.00%
• MW: Approxiamtely 22.9 kDa
• Biological Activity: FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the collagen VI-related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other hand.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.