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Finasteride

SKU: orb1223484

Description

Finasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM).(In Vitro):Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells.Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT) in P. crustosum.(In Vivo):Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number98319-26-7
MW372.55
Purity>98% (HPLC)
FormulaC23H36N2O2
SMILESC[C@]12CC[C@H]3[C@@H](CC[C@@H]4[C@]3(C)C=CC(N4)=O)[C@@H]1CC[C@@H]2C(NC(C)(C)C)=O
TargetReductase
SolubilityEthanol: 75 mg/mL (201.32 mM); DMSO: 75 mg/mL (201.32 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MK-906 | Propecia | Proscar

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Finasteride (orb1223484)

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100 mg
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