Factor XII antibody

• Catalog Number: orb21989
• Category: Antibodies
• Description: Goat polyclonal antibody to Factor XII.
• Species/Host: Goat
• Clonality: Polyclonal
• Form/Appearance: Delipidated, heat inactivated, lyophilized, stable whole serum. No preservative added. Total protein concentration in the antiserum is about 50 mg/ml, the IgG concentration about 10 mg/ml. No foreign proteins added.
• Conjugation: Unconjugated
• Hazard Information: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• UniProt ID: P00748
• Source: Factor XII (Hageman factor) is a single chain glycoprotein (MW 80,000). It is a serine protease zymogen. FXII is converted to an active enzyme by damage to vascular endothelium. In vitro activation is caused by glass or kaolin. Surface binding promotes activation by kallikrein. FXIIa activates prekallikrein and FXI. Kallikrein activates more FXII. Fragments of FXIIa activate FVII to FVIIa, and plasminogen to plasmin. The complement system is also activated by FXIIa. A link between fibrin clot and the subendothelium is formed by FXIIa crosslinking with fibrin, alpha-2 plasmin inhibitor, fibronectin and Van Willebrand factor. Purified plasma FXII is used as immunogen. Freund’s complete adjuvant is used in the first step of the immunization procedure.
• Storage: Storage: The lyophilized antiserum is shipped at ambient temperature and may be stored at +4°C; prolonged storage at or below -20°C. Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at +4°C, not refrozen, and preferably used the same day
• Buffer/Preservatives: Delipidated, heat inactivated, lyophilized, stable whole serum. No preservative added. Total protein concentration in the antiserum is about 50 mg/ml, the IgG concentration about 10 mg/ml. No foreign proteins added.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.