Edetate?Trisodium

SKU: orb1226174

Description

Ethylenediaminetetraacetic acid (EDTA) trisodium salt is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.

Key Properties

• CAS Number: 150-38-9
• MW: 358.19
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₃N₂Na₃O₈
• SMILES: O.O.[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O
• Target: metal ion
• Solubility: Soluble in Water

Bioactivity

• In Vivo:
  Animal model: Male Wistar rat model of cirrhosis induced by CCl4. Dosage: 60 mg/kg, 120 mg/kg, 240 mg/kg. Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks). Result: Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg. Reduced fibrosis of the liver in surviving rats (20%). Animal model: Male Wistar rat model of cirrhosis induced by CCl. Dosage: 60 mg/kg. Administration: Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days). Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days). Result: Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group). Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

metal ion