Droxidopa

SKU: orb1225560

Description

Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 23651-95-8
• MW: 213.19
• Purity: >98% (HPLC)
• Formula: C₉H₁₁NO₅
• SMILES: O=C(O)[C@H](N)[C@H](C1=CC=C(O)C(O)=C1)O
• Target: Adrenergic Receptor
• Solubility: Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  Droxidopa (200 mg/kg; i.p.) alters dopamine neuron and prefrontal cortex activity and improves attention-deficit/hyperactivity disorder-like behaviors in rats. Droxidopa (10, 20 mg/kg; i.p.) significantly increases the paw withdrawal latency and inhibits mechanical hypersensitivity to thermal stimulation in 6-OHDA-lesioned rats at the 5th week after surgery. Animal model: 250-380g male Sprague-Dawley rats. Dosage: 200 mg/kg (10 mg/kg, i.p. benserazide was given to the animals at 20 or 30 min prior to L-DOPS injection). Administration: i.p. Result: Significantly decreased hyperactivity of BZ-pretreated SHR/NCrl at 30 (P < 0.01) and 40 min (P < 0.05) post-injection, improved inattention-like behavior of SHR/NCrl, and ameliorated impulsive-like behavior of SHR/NCrl and Wistar rats.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L-DOPS | SM 5688

Quick Database Links

Gene Symbol

Adrenergic Receptor