DQP-997-74

• Catalog Number: orb1942238
• Category: Small Molecules
• Description: Dihydroquinoline-pyrazoline DQP-997-74 (compound 2i) is a selective N-methyl-d-aspartate receptor (NMDAR) inhibitor that preferentially targets GluN2C/D subunits, with IC50 values of 0.069 μM and 0.035 μM, respectively, and possesses blood-brain barrier permeability. It enhances its inhibitory potency in a time-dependent manner when combined with the agonist glutamate, reducing epileptogenic events in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 is potentially applicable for the study of NMDAR-related neurological diseases [1].
• Purity: 98.00%
• MW: 570.37
• Biological Activity: Dihydroquinoline-pyrazoline DQP-997-74 (compound 2i) is a selective N-methyl-d-aspartate receptor (NMDAR) inhibitor that preferentially targets GluN2C/D subunits, with IC50 values of 0.069 μM and 0.035 μM, respectively, and possesses blood-brain barrier permeability. It enhances its inhibitory potency in a time-dependent manner when combined with the agonist glutamate, reducing epileptogenic events in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 is potentially applicable for the study of NMDAR-related neurological diseases [1].
• CAS Number: 2377187-09-0
• Formula: C₂₈H₁₉Cl₂F₂N₃O₄
• SMILES: O=C(O)CC(F)(F)C(=O)N1N=C(C=2C(=O)NC=3C=CC=CC3C2C=4C=CC(Cl)=CC4)CC1C5=CC=C(Cl)C=C5
• Storage: -20°C
• Note: For research use only