Doramapimod (BIRB-796)

• Catalog Number: orb251412
• Category: Small Molecules
• Description: BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.
• CAS Number: [285983-48-4]
• MW: 527.66
• SMILES: O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3
• Formula: C₃₁H₃₇N₅O₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Chemical structure of Doramapimod (BIRB-796)