DOPE

SKU: orb1307144

Description

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Research Area

Metabolism Research

Key Properties

• CAS Number: 4004-05-1
• MW: 744.03
• Purity: 97.23%
• Formula: C₄₁H₇₈NO₈P
• SMILES: CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
• Target: Endogenous Metabolite,Others,Liposome
• Solubility: Ethanol:10 mg/mL (13.44 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Helper lipid for liposome:
• In Vitro:
  Each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent). Wit the neutral lipid fo the LNP is DOPE, LNP exerts knock-down (KD) effect on macrophages and DCs and Liposome-containing DOPE shows fusogenicity. LNP/siRNA significantly suppresses CD45 protein expression at an Inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
• Disclaimer: For research use only

Alternative Names

1,2Dioleoylsnglycero3phosphoethanolamine, 1,2 Dioleoyl sn glycero 3 phosphoethanolamine, cationic, DNA, dioleoylphosphatidylethanolamine, Inhibitor, emulsifier, liposome, knock-down, inhibit, transfection, siRNA, phospholipid

Compound Identifiers

PubChem CID

9546757