DODAP

SKU: orb1691847

Description

DODAP

Research Area

Metabolism Research

Key Properties

• CAS Number: 127512-29-2
• MW: 648.05
• Purity: 98.70%
• Formula: C₄₁H₇₇NO₄
• SMILES: C(OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)CN(C)C
• Target: Liposome
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.09 mM);DMSO:80 mg/mL (123.45 mM);Ethanol:80 mg/mL (123.45 mM)

Bioactivity

• In Vivo:
  Mice were injected with DODAP-LNPs (0.5 mg/kg mRNA, 200 μL); after 24 h, luciferase expression was mainly in liver and spleen but lower than MC3-LNP.
• In Vitro:
  DODAP-based LNPs delivered luciferase mRNA to HEK293T cells for 24 h; luciferase expression was lower than MC3-LNPs, indicating reduced transfection efficienc.

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
• Disclaimer: For research use only

Alternative Names

DODAP

Compound Identifiers

PubChem CID

9895790