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Catalog Number | orb1821772 |
---|---|
Category | Antibodies |
Description | Mertansine (DM-1) is a tubulin inhibitor that binds to the ends of microtubules and inhibits microtubule dynamics. DM-1(Mertansine) has antitumor activity and functions as a regulator of tubulin. It is an alpha-amino acid ester, a carbamate, an epoxide, an organic heterocyclic tetracyclic compound, an organochlorine compound, a mercaptan, and a maydenin alkaloid. DM-1, derived from Mydenin, is a cytotoxic component of antibody-drug conjugations that produce antibody-drug conjugations via a sulfhydryl group splice with SPP (n-succinimide 4- (2-pyridyl dithio)) or SMCC (4- (3-mercapto-2, 5-dioxy-1 pyrrolidyl) -cyclohexanic acid) splice. |
Clonality | Recombinant |
Reactivity | Mouse |
Isotype | Mouse IgG1 | Mouse Kappa |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Biotin |
Target | DM-1 |
Source | Mertansine (DM-1) is a tubulin inhibitor that binds to the ends of microtubules and inhibits microtubule dynamics. DM-1(Mertansine) has antitumor activity and functions as a regulator of tubulin. It is an alpha-amino acid ester, a carbamate, an epoxide, an organic heterocyclic tetracyclic compound, an organochlorine compound, a mercaptan, and a maydenin alkaloid. DM-1, derived from Mydenin, is a cytotoxic component of antibody-drug conjugations that produce antibody-drug conjugations via a sulfhydryl group splice with SPP (n-succinimide 4- (2-pyridyl dithio)) or SMCC (4- (3-mercapto-2, 5-dioxy-1 pyrrolidyl) -cyclohexanic acid) splice. |
Expression System | Hybridoma |
Endotoxins | 1.0 EU per μg |
Storage | -20°C |
Buffer/Preservatives | PBS, pH 7.4 |
Note | For research use only |
Application notes | ELISA |
Expiration Date | 12 months from date of receipt. |
ELISA, ICC, IHC-Fr, IHC-P | |
Bovine, Canine, Human, Porcine, Rat, Sheep | |
Mouse | |
Rabbit | |
Polyclonal | |
Biotin |
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