DLin-MC3-DMA

SKU: orb507413

Description

D-Lin-MC3-DMA(MC3) is the most potent cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA.

Images & Validation

• Application Notes:
  D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Key Properties

• CAS Number: 1224606-06-7
• MW: 641.61
• Purity: >98%
• Formula: C₄₃H₇₉NO₂
• SMILES: CCCCC/C=C\C/C=C\CCCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC/C=C\C/C=C\CCCCC

Storage & Handling

• Storage: Pure form: -20°C/3 years,4°C/2 years; In solvent: -20°C/1 month
• Hazard Information: Non-Toxic
• Disclaimer: For research use only

Alternative Names

1224606-06-7, D-Lin-MC3-DMA, (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

Chemical structure of DLin-MC3-DMA

References

Ye Zeng 1, Mariona Estapé Senti 2, M Clara I Labonia 3, Panagiota Papadopoulou 1, Maike A D Brans 3, Inge Dokter 3 4, Marcel H Fens 5, Alain van Mil 3 4, Joost P G Sluijter 3 4, Raymond M Schiffelers 2, Pieter Vader 2 3, Alexander Kros 1 Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration ACS Nano, 17(23), 23466–23477 (2023)

PubMed: 37982378

Applications

Cell Screening

Reactivity

Human

Gangyin Zhao 1 2, Ye Zeng 3, Wanli Cheng 4, Sofia Karkampouna 4 5, Panagiota Papadopoulou 3, Bochuan Hu 3, Shuya Zang 3, Emma Wezenberg 3, Gabriel Forn-Cuní 1, Bruno Lopes-Bastos 1, Marianna Kruithof-de Julio 5, Alexander Kros 3, B Ewa Snaar-Jagalska 1 Peptide-Modified Lipid Nanoparticles Boost the Antitumor Efficacy of RNA Therapeutics ACS Nano, (2025)

PubMed: 40176316

Hend Mohamed Abdel-Bar et al. Optimizing Exosome Lipid Hybrid Nanoparticles for Enhanced siRNA Delivery and Improved Therapeutic Anticancer Efficacy In Vivo ACS Nano, 19(50), 42658-42674 (2025)

PubMed: 41378821

Applications

Cell Screening

Reactivity

Mouse