β,β-Dimethylacrylshikonin

SKU: orb1303348

Description

Dimethylacrylshikonin is a bioactive small molecule that demonstrates anti-tumor activity both in vitro and in vivo. It induces apoptosis in cancer cells like MCF-7 and SGC-791 by modulating Bcl-2/Bax, ERK, and NF-κB pathways, and enhances radiotherapy efficacy in HCT-116 xenograft models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 24502-79-2
• MW: 370.396
• Purity: 99.97%
• Formula: C₂₁H₂₂O₆
• SMILES: O=C1C=2C(C(=O)C=C1[C@H](OC(C=C(C)C)=O)CC=C(C)C)=C(O)C=CC2O
• Target: NO Synthase,HIF/HIF Prolyl-Hydroxylase,Gamma-secretase,Bcl-2 Family,ERK,Apoptosis
• Solubility: DMSO:8.55 mg/mL (23.08 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta, beta-Dimethylacrylshikonin, beta,beta-Dimethylacrylshikonin, Dimethylacrylshikonin, b, b-Dimethylacrylshikonin, b,b-Dimethylacrylshikonin, inhibit, Isoarnebin I, HIFProlylHydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF-1α, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF, Inhibitor, ERK, β, β-Dimethylacrylshikonin, β,β Dimethylacrylshikonin, β,βDimethylacrylshikonin, β,β-Dimethylacrylshikonin

Compound Identifiers

PubChem CID

138911417