β,β-Dimethylacrylshikonin

SKU: orb1303348

Description

Dimethylacrylshikonin is a bioactive small molecule that demonstrates anti-tumor activity both in vitro and in vivo. It induces apoptosis in cancer cells like MCF-7 and SGC-791 by modulating Bcl-2/Bax, ERK, and NF-κB pathways, and enhances radiotherapy efficacy in HCT-116 xenograft models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 24502-79-2
• MW: 370.396
• Purity: 93.42% (May vary between batches)
• Formula: C₂₁H₂₂O₆
• SMILES: C\C(C)=C/C[C@@H](OC(=O)\C=C(\C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O
• Target: NO Synthase,HIF/HIF Prolyl-Hydroxylase,Bcl-2 Family,Gamma-secretase,ERK,Apoptosis
• Solubility: DMSO:8.55 mg/mL (23.08 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta, beta-Dimethylacrylshikonin, beta,beta-Dimethylacrylshikonin, Dimethylacrylshikonin, b, b-Dimethylacrylshikonin, b,b-Dimethylacrylshikonin, inhibit, Isoarnebin I, HIFProlylHydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF-1α, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF, Inhibitor, ERK, β, β-Dimethylacrylshikonin, β,β Dimethylacrylshikonin, β,βDimethylacrylshikonin, β,β-Dimethylacrylshikonin

Compound Identifiers

PubChem CID

138911417