Diclofenac Potassium

SKU: orb1300740

Description

Diclofenac Potassium is a nonsteroidal anti-inflammatory drug (NSAID) used in research to study analgesia and inflammation. It is widely applied in both in vitro and in vivo models to investigate cyclooxygenase (COX) inhibition, pain pathways, and inflammatory responses.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 15307-81-0
• MW: 334.24
• Purity: 99.93% (May vary between batches)
• Formula: C₁₄H₁₀Cl₂KNO₂
• SMILES: [K+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl
• Target: Apoptosis,COX
• Solubility: H2O:10 mg/mL (29.92 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.98 mM);DMSO:55 mg/mL (164.55 mM)

Bioactivity

• Target IC50:
  COX-1 (ovine):5.1 nM (IC50)|COX-2(human):1.3 nM (IC50, in CHO cells)|COX-1 (ovine):0.84 nM (IC50)|COX-1 (human):4 nM (IC50, in CHO cells)
• In Vitro:
  The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, neural, ovine, NSCs, COX, COX-2, COX-1, Cyclooxygenase, Diclofenac Potassium, Diclofenac, cells, CGP-45840B, cascade, Cataflam, caspase, CHO, Apoptosis, anti-inflammatory, stem, Voltfast

Compound Identifiers

PubChem CID

23667642