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Catalog Number | orb864223 |
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Category | Small Molecules |
Description | Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is clinically used to treat inflammation associated with arthritis and gout as well as other pain or inflammatory disorders; it is somewhat selective in inhibiting COX-2 over COX-1. Diclofenac exhibits anti-inflammatory, antipyretic, analgesic, antinociceptive, anticonvulsant, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In vitro, the anticonvulsant/antiepileptic activity of diclofenac may stem from inhibition of delayed rectifier K+ channel amplitude and acceleration of channel inactivation; it also increases the amplitude of M-type K+ channels. This compound inhibits DMH-induced colon carcinogenesis in vivo, decreasing levels of COX-2, VEGF, and MCP-1. Diclofenac also decreases the epithelial-to-mesenchymal transition (EMT), suppressing squamous cell carcinoma tumor growth. |
CAS Number | 15307-86-5 |
Purity | ≥99% |
MW | 296.15 |
SMILES | c1ccc(c(c1)CC(=O)O)Nc2c(cccc2Cl)Cl |
Hazard Information | Non-Toxic |
Solubility (25°C) | Insoluble in water. Soluble in DMSO. |
Storage | Storage Temp: Ambient |
Alternative names | Voltarol Read more... |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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