Dichlorphenamide

SKU: orb1222809

Description

Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class. Diclofenamide is used to treat glaucoma and therapy-resistant epilepsy.(In Vivo):Dichlorphenamide can reduce IOP locally in male albino rabbits.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 120-97-8
• MW: 305.16
• Purity: >98% (HPLC)
• Formula: C₆H₆Cl₂N₂O₄S₂
• SMILES: c1c(cc(c(c1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N
• Target: Prostaglandin Receptor
• Solubility: DMSO : ≥ 28 mg/mL; 91.76 mM

Bioactivity

• In Vivo:
  Dichlorphenamide can reduce IOP locally in male albino rabbits. Animal model: Male albino rabbits (approximately 2.5 kg). Dosage: 50 μL 10% aqueous solutions of dichlorphenamide sodium or 2 mg/kg, 6 mg/kg. Administration: Eye drop of 50 μL or Oral gavage of 2 mg/kg or 6 mg/kg, 5 hours. Result: Showed significant decrease in IOP at 30 min by instilling into eyes and decrease in IOP only at 1 h by orally after drug administration, and demonstrated that drug levels were significantly higher in the iris ciliary body and lower in the serum by instilling compared to oral administration.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dichlorphenamide | Diclofenamide

Quick Database Links

Gene Symbol

Prostaglandin Receptor