Dexpramipexole dihydrochloride

• Catalog Number: orb1146459
• Category: Small Molecules
• Description: Dexpramipexole 2Hcl(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.
• CAS Number: [104632-27-1]
• MW: 284.249
• SMILES: Cl.Cl.CCCNC1CC2=C(CC1)N=C(=N)S2
• Formula: C₁₀H₁₉Cl₂N₃S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.