You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb67083 |
---|---|
Category | Antibodies |
Description | Rabbit polyclonal to DEF6.Differentially expressed in FDCP 6 (DEF6) is also known as SWAP-70-like adapter of T-cells (SLAT), which is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF). DEF6 plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42, and regulates cell morphology in cooperation with activated RAC1. DEF6 also plays a role in Th2 (T helper cells) development and/or activation by interfering with ZAP70 signaling. DEF6 is required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of sytemic autoimmunity. Defects in DEF6 results in spontaneous development of a lupus-like syndrome in aging female mice. |
Species/Host | Rabbit |
Clonality | Polyclonal |
Tested applications | WB |
Reactivity | Mouse |
Immunogen | C-terminal region of mouse DEF6 |
Dilution range | WB:1:1000-1:3000 |
Purity | Affinity purification |
Conjugation | Unconjugated |
MW | 73 |
UniProt ID | Q8C2K1 |
Storage | -20°C |
Buffer/Preservatives | 0.01% NaN3 |
Alternative names | anti-DEF6 antibody,anti-Differentially expressed i Read more... |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
Western blot analysis of total cell extracts from mouse thymus using DEF6 antibody
ELISA, WB | |
Bovine, Canine, Human, Mouse, Porcine, Rat | |
Goat | |
Polyclonal | |
Unconjugated |
Filter by Rating