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DCN Antibody / Decorin
Catalog Number: orb2635536
| Catalog Number | orb2635536 |
|---|---|
| Category | Antibodies |
| Description | Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGF may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope. |
| Species/Host | Rabbit |
| Clonality | Recombinant |
| Clone Number | DCN/7031R |
| Tested applications | IHC-P |
| Reactivity | Human |
| Isotype | Rabbit IgG |
| Immunogen | A portion of amino acids 212-336 was used as the immunogen for the DCN antibody. |
| Antibody Type | Primary Antibody |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml |
| Conjugation | Unconjugated |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Hazard Information | This DCN antibody is available for research use only. |
| UniProt ID | P07585 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Note | For research use only |
| Application notes | Optimal dilution of the DCN antibody should be determined by the researcher. |
| Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human prostate carcinoma tissue with DCN antibody (clone DCN/7031R). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free DCN antibody (clone DCN/7031R) as confirmation of integrity and purity.
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